Interferon- as an immunotherapeutic protein
نویسندگان
چکیده
Interferon(IFN) has proven to be a clinically effective antiviral and antineoplastic therapeutic drug for more than 16 years. During this time, evidence from in vitro laboratory studies and the clinical arena has supported the concept that IFNis an immunotherapeutic drug. By regulating a diverse set of cytokines and their receptors, IFNis uniquely positioned to prime the host immune response and provide an effective antineoplasticand antiviral-immune response. IFNstimulates the innate cell-mediated response and then participates in the transition of the initial host innate response into an effective adaptive-immune response. IFNalso drives the adaptive cell-mediated CD8 T-cell response and helps to maintain a CD4 Th1-cell population balance for an effective antineoplastic and antiviral host defense. This review will describe the current state of knowledge of IFNas an immunoregulatory protein and address specific issues of IFNas an immunotherapeutic for antineoplastic and antiviral diseases. J. Leukoc. Biol. 71: 565–581; 2002.
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